Enterobacter aerogenes ZDY01 Attenuates Choline-Induced Trimethylamine N-Oxide Levels by Remodeling Gut Microbiota in Mice

May 17, 2017Journal of microbiology and biotechnology

Enterobacter aerogenes ZDY01 reduces choline-related harmful compound levels by changing gut bacteria in mice

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Abstract

Serum TMAO levels decreased significantly in choline-fed mice treated with ZDY01 compared to those treated with phosphate-buffered saline.

TMAO, linked to atherosclerosis, is formed from TMA, which is produced by gut microbes from certain dietary components.
A total of 82 bacterial isolates were screened, primarily from the Enterobacteriaceae family, for their ability to utilize TMA.
Treatment with ZDY01 resulted in a significant reduction of both serum TMAO and cecal TMA levels in mice.
Administration of ZDY01 altered gut microbiota, increasing the family S24-7 while decreasing Helicobacteraceae and Prevotellaceae.
Probiotics may offer a novel method to reduce TMAO levels in the body and potentially prevent associated health issues.

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Trimethylamine-oxide (TMAO), which is transformed from trimethylamine (TMA) through hepatic flavin-containing monooxygenases, can promote atherosclerosis. TMA is produced from dietary carnitine, phosphatidylcholine, and choline via the gut microbes. Previous works have shown that some small molecules, such as allicin, resveratrol, and 3,3-dimethyl-1-butanol, are used to reduce circulating TMAO levels. However, the use of bacteria as an effective therapy to reduce TMAO levels has not been reported. In the present study, 82 isolates were screened from healthy Chinese fecal samples on a basal salt medium supplemented with TMA as the sole carbon source. The isolates belonged to the family Enterobacteriaceae, particularly to genera, and. Serum TMAO and cecal TMA levels were significantly decreased in choline-fed mice treated withZDY01 compared with those in choline-fed mice treated with phosphate-buffered saline. The proportions of Bacteroidales family S24-7 were significantly increased, whereas the proportions of Helicobacteraceae and Prevotellaceae were significantly decreased through the administration ofZDY01. Results indicated that the use of probiotics to act directly on the TMA in the gut might be an alternative approach to reduce serum TMAO levels and to prevent the development of atherosclerosis and "fish odor syndrome" through the effect of TMA on the gut microbiota. N Klebsiella, Escherichia, Cronobacter Enterobacter Enterobacter aerogenes E. aerogenes

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Enterobacter aerogenes ZDY01 Attenuates Choline-Induced Trimethylamine N-Oxide Levels by Remodeling Gut Microbiota in Mice

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