Enterobacter aerogenes ZDY01 inhibits choline-induced atherosclerosis through CDCA-FXR-FGF15 axis

Sep 7, 2021Food & function

Enterobacter aerogenes ZDY01 may reduce artery plaque caused by choline through a specific liver-intestine signaling pathway

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Abstract

ZDY01 reduced serum trimethylamine-oxide (TMAO) levels by decreasing cecal trimethylamine (TMA) in ApoE mice fed with 1.3% choline.

  • ZDY01 inhibited choline-induced atherosclerosis in ApoE mice.
  • The treatment decreased cecal TMA and serum TMAO levels by utilizing cecal TMA as a nutrient.
  • ZDY01 did not change the expression of hepatic FMO3 or the gut microbiota composition.
  • The compound enhanced the expression of bile acid transporters and reduced cecal CDCA levels.
  • ZDY01 attenuated the FXR/FGF15 pathway, leading to increased expression of Cyp7a1.
  • These changes promoted reverse cholesterol transport.

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