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LC-ESI-MS/MS on an ion trap for the determination of LSD, iso-LSD, nor-LSD and 2-oxo-3-hydroxy-LSD in blood, urine and vitreous humor
Measuring LSD and its related compounds in blood, urine, and eye fluid using advanced mass spectrometry
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Abstract
A method has been developed that achieves limits of quantification of 20 pg/ml for LSD and nor-LSD in blood, urine, and vitreous humor.
- The method enables the simultaneous detection of LSD, iso-LSD, nor-LSD, and their metabolites in various biological fluids.
- It utilizes liquid/liquid extraction and liquid chromatography with mass spectrometry for analysis.
- No significant interference or ion suppression was detected for the substances of interest.
- Interassay reproducibility for LSD at 20 pg/ml and 2 ng/ml in urine was measured at 8.3% and 5.6%, respectively.
- Mean recoveries for LSD across different fluids ranged from 50-107%.
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