Automated extraction of lysergic acid diethylamide (LSD) and N-demethyl-LSD from blood, serum, plasma, and urine samples using the Zymark RapidTrace with LC/MS/MS confirmation.
Automated detection of LSD and its main breakdown product in blood and urine samples confirmed by chemical analysis
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Abstract
The limit of quantitation (LOQ) for LSD was 0.05 ng/mL.
- A forensic procedure confirms the presence of LSD and its metabolite, N-demethyl-LSD, in various biological samples.
- Both LSD and N-demethyl-LSD have a limit of detection (LOD) of 0.025 ng/mL.
- The recovery rate for LSD exceeds 95% at concentrations of 0.1 ng/mL and 2.0 ng/mL.
- At a concentration of 1.0 ng/mL, the within-run relative standard deviation (RSD) is 2.2%, while the between-run RSD is 4.4%.
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