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Abstract
Lipid nanoparticles (LNPs) have shown significant success in delivering messenger RNA (mRNA) for cancer immunotherapy.
- LNPs are crucial for enhancing mRNA stability and facilitating its delivery into cells.
- The efficiency of endosomal escape and passive targeting remains a challenge in mRNA delivery.
- Key advancements in LNP design include optimization of chemical structures for improved transfection.
- Factors influencing the effectiveness of mRNA-loaded LNPs include transfection efficiency and tropism.
- Both preclinical and clinical applications of mRNA LNPs in cancer immunotherapy are discussed.
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