Full text is available at the source.
Customizable Fat-Based Nanoparticles for Efficient RNA Delivery to Specific Organs
Updated
Abstract
The optimal lipopeptide-based organ-specific targeting LNP shows excellent siRNA/mRNA transfecting ability in various hard-to-transfect cell lines.
- Lipid nanoparticles (LNPs) with specific targeting capabilities are being developed for gene delivery.
- Lipopeptides (LPs) are designed to enhance the functionality of LNPs through modular design.
- The newly developed lysine-histidine-based lipopeptides (KH-LPs) serve as efficient components for targeting.
- POST LNPs demonstrate higher or comparable efficiency in delivering mRNA and siRNA to the lung, liver, and spleen compared to classic LNPs.
- The structure-activity relationship indicates that modular regulation of LP structures can optimize targeting lipid systems.
Simplified