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Liposomal lipid nanoparticles for extrahepatic delivery of mRNA
Lipid nanoparticles designed to deliver mRNA outside the liver
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Abstract
Lipid nanoparticle (LNP) systems with a bilayer lipid to ionizable lipid molar ratio of 4 demonstrate 90-100% mRNA encapsulation efficiencies and excellent transfection potencies in vitro.
- prepared at specific ratios exhibit a liposomal structure with a solid core and aqueous interior.
- These liposomal LNPs have longer circulation lifetimes compared to those with Onpattro-like lipid compositions.
- Enhanced transfection properties in extrahepatic tissues are observed in these liposomal LNPs.
- The prolonged blood circulation is linked to reduced plasma protein adsorption.
- Transfection competency is related to the release of the solid core containing mRNA as the endosomal pH decreases.
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Key numbers
90-100%
mRNA Encapsulation Efficiency
Encapsulation efficiency of LNP mRNA systems with bilayer to ionizable lipid ratio of 4.
15×
Circulation Lifetime Increase
Circulation half-life of liposomal compared to Onpattro-like formulations.