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Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice
Long-term treadmill exercise slows Alzheimer’s-like brain damage in memory areas of genetically modified mice
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Abstract
Five months of treadmill exercise resulted in a robust reduction in β-amyloid deposition and tau phosphorylation in the hippocampus of APP/PS1 mice.
- Treadmill running may inhibit the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 mice.
- Exercise was associated with a significant decrease in the phosphorylation of amyloid precursor protein (APP) and expression of presenilin 1 (PS1).
- Inhibition of GSK3 was observed, while CDK5 was not affected by treadmill exercise.
- The findings suggest that exercise could mediate APP processing, leading to reduced β-amyloid deposition.
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