Treadmill exercise may reduce harmful protein buildup in Alzheimer’s model mice by affecting cell stress responses

Three months of treadmill exercise resulted in a robust reduction in Aβ plaques and soluble forms of Aβ in the hippocampus of APP/PS1 mice.

• Exercise led to a significant decrease in the expression of BACE1 and presenilin-1, which are involved in amyloid production.
• Treadmill exercise down-regulated the expression of GRP78, indicating a potential modulation of the unfolded protein response (UPR).
• Activation of UPR signaling pathways, including PERK, eIF2α, and ATF4, was inhibited following the exercise regimen.
• The findings suggest a possible link between exercise, UPR signaling, and amyloid reduction in a mouse model of Alzheimer's disease.

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