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Abstract
Middle-aged mice with mutations in the period genes (Per1 and Per2) show lower reproductive success compared to wild-type mice.
- Young adult Per mutant females have similar fecundity to wild-type females.
- Middle-aged Per mutant females exhibit irregularities in their oestrous cycle.
- These irregularities may lead to lower reproductive success in middle-aged Per mutant females.
- Per mutant females have more embryonal implantations but fewer successfully delivered offspring.
- The reproductive deficits observed in middle-aged Per mutants resemble those of aged wild-type mice.
- Mutations in Per1 and Per2 may be associated with advanced ageing effects on reproduction.
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