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Abstract
Rising global life expectancy is associated with significant health impacts due to aging of the female lower reproductive tract.
- Estrogen depletion may trigger hormonal imbalance and chronic inflammation.
- Cellular aging processes are linked to structural degeneration in reproductive tissues.
- Uterine fibrosis and endometrial atrophy could result from these aging mechanisms.
- Aging may increase cervical susceptibility to persistent HPV infections and cancer development.
- Disruption of the vaginal microbiome is observed alongside these changes.
- Future research should focus on causal links between immune aging and specific tissue pathologies.
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