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Abstract
Analysis of 1,112 histology images reveals that the uterus experiences an abrupt molecular and morphological shift around menopause.
- The ovary shows gradual aging while the uterus undergoes a sudden transformation at menopause.
- Plasma proteomics data from a large population cohort supports the presence of organ-specific aging markers in blood.
- The myometrium is significantly affected by age, with changes in the extracellular matrix and immune system activation.
- Epithelial tissues demonstrate coordinated age-related changes, particularly notable in the vaginal epithelium during menopause.
- Multi-omics analysis connects histological transformations to nonlinear shifts in gene expression related to reproductive health.
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