We can’t show the full text here under this license.
Role of the m6A RNA modifier ALKBH5 in digestive system cancers
Updated
Abstract
N6‑methyladenosine (mA) is a key internal modification in RNA that influences several critical biological processes.
- mA is involved in RNA export, splicing, stability, gene expression, microRNA production, and long non-coding RNA metabolism.
- ALKBH5 functions as a demethylase for mA and is linked to various biological processes related to tumor progression.
- The role of ALKBH5 is particularly significant in human digestive system tumors, affecting their post-transcriptional regulation.
- Dysregulation of ALKBH5 may contribute to tumor metastasis, immunity, and resistance to treatment.
- Targeting ALKBH5 could lead to new approaches in clinical prognosis, biomarker identification, and treatment strategies for gastrointestinal cancers.
Simplified