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Abstract
Macrophages play a critical role in both allograft rejection and tolerance in organ transplantation.
- Allograft rejection involves complex interactions between innate and adaptive immune cells.
- Macrophages contribute to ischemia-reperfusion injury and both acute and chronic rejection of transplanted organs.
- These cells exhibit a phenomenon known as 'trained immunity,' enhancing their inflammatory responses upon subsequent exposures.
- Macrophages can also adopt immunoregulatory roles, which may facilitate allograft tolerance.
- Understanding macrophage plasticity and polarization is essential for developing targeted therapies in transplantation.
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