Innate immunity in solid organ transplantation: an update and therapeutic opportunities

Innate immunity is increasingly recognized as a major player in transplantation.

• Innate immunity contributes to inflammation during the early post-transplant phase.
• It influences how adaptive immune cells develop, potentially leading to either rejection or tolerance of the transplant.
• Recent findings suggest that innate allorecognition is linked to allograft rejection.
• The review discusses the physiology of innate immune components related to transplantation.
• Current and promising therapies include cellular treatments, anticomplement agents, and anticytokine strategies.

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