Full text is available at the source.
Innate allorecognition by monocytic cells and its role in graft rejection
How certain immune cells naturally recognize and react to transplanted tissue during rejection
AI simplified
Abstract
Monocytes and macrophages may recognize allogeneic grafts through innate allorecognition mechanisms involving the molecule signal regulatory protein α (SIRPα).
- Monocytes and macrophages are known to recognize microbial products and danger signals.
- They may also respond directly to allogeneic grafts, leading to graft rejection.
- Recent evidence suggests these immune cells can mediate graft rejection through direct cell damage and activation of alloreactive T cells.
- The recognition mechanism involves detecting the polymorphic molecule SIRPα on donor cells.
- Understanding this innate allorecognition could enhance knowledge of allograft rejection.
AI simplified