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Innate allorecognition in transplantation
Natural immune recognition of transplanted tissue
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Abstract
Understanding innate immune recognition in transplantation could improve allograft survival.
- Successful allogeneic transplantation relies on suppressing the adaptive immune system.
- Current treatments primarily target T and B cells to prevent organ rejection.
- The innate immune system, including dendritic cells and natural killer cells, initiates the adaptive immune response.
- Recent findings indicate that the innate immune system can recognize nonself tissue.
- Mechanisms of innate allorecognition have been partially uncovered, suggesting new treatment strategies.
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