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How the Mammal Body Clock Works at the Molecular Level for Medicine and Drug Development
Updated
Abstract
Circadian rhythms are a fundamental aspect of life, demonstrated by their presence across various kingdoms.
- Circadian rhythms are generated through complex feedback loops involving clock genes in most body cells.
- The hypothalamic suprachiasmatic nucleus (SCN) is crucial for maintaining these rhythmic oscillations.
- Lesions in the SCN disrupt the body’s clock, leading to loss of rhythm.
- Disruption of circadian systems is linked to abnormal expression of specific genes associated with lifestyle-related diseases.
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