The mammalian clock and chronopharmacology

Mar 14, 2013Bioorganic & medicinal chemistry letters

The body’s internal clock and how timing affects drug responses

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Abstract

Recent advances in understanding the molecular control of circadian rhythms may lead to new therapeutic drug targets.

  • The molecular clock in mammals plays a critical role in regulating circadian rhythms.
  • Targeting components of the molecular clock could enhance the development of novel therapeutics.
  • Circadian rhythms may influence the effectiveness and safety of existing drugs.
  • Improved knowledge of these mechanisms is associated with the potential for more efficacious drug utilization.

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