Protective effect of maternal prenatal melatonin administration on rat pups born to mothers submitted to constant light during gestation

Aug 31, 2010Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

Maternal melatonin given during pregnancy may protect rat pups from effects of constant light exposure

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

LL offspring exhibited a 44.7% decrease in open-arm entries indicating anxiety-like behavior.

  • LL offspring lacked circadian rhythms of malate and lactate dehydrogenase activities.
  • Anxiety-like behavior was significantly higher in LL offspring, shown by reduced entries and time in open arms during the elevated plus-maze test.
  • LL offspring showed increased latencies for mounting, intromission, and ejaculation behaviors compared to control offspring.
  • The LL+Mel group demonstrated restored circadian rhythms of dehydrogenase activities and showed anxiety-like and sexual behaviors similar to control.
  • Melatonin may play a protective role during prenatal development by influencing circadian rhythms and behavior in offspring.

AI simplified

Full Text

Full text is available at the source.
View full text ↗

Related papers

Mar '13
Disrupted daily rhythms during primate pregnancy linked to changes in mother and newborn body temperature patterns
top 30% journal
cited by 33 papers
research support, non-u.s. gov't
Jul '15
Melatonin changes daily movement patterns under constant light depending on early-life lighting conditions
cited by 3 papers
research support, non-u.s. gov't
Aug '16
Long-term behavior and brain changes in adult rats exposed to constant light before birth
cited by 45 papers
research support, non-u.s. gov't
Aug '18
Lack of mother's daily melatonin cycle during pregnancy and breastfeeding may harm offspring growth, brain development, and behavior
top 30% journal
cited by 60 papers
research support, non-u.s. gov't
Sep '10
Pregnant rats’ limited feeding schedule aligns their fetuses’ internal clocks in constant light but not in normal day-night cycles
cited by 44 papers
research support, non-u.s. gov't

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #35
Bacteria exposure resets your internal clock independently of immune responses
3 days ago7 studies
issue #34
Night owl teens got 47 minutes more sleep with bright light glasses
1 week ago7 studies
issue #33
Working out at your optimal time cuts blood pressure twice as much
2 weeks ago7 studies
issue #32
Bright light preference disrupts mouse sleep patterns even without human lifestyle factors
3 weeks ago7 studies
issue #31
Artificial light at night disrupts bird sleep and metabolism across 675 studies
4 weeks ago7 studies
issue #30
Your hair can reveal your circadian rhythm from a single sample
5 weeks ago7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
6 weeks ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
7 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
8 weeks ago7 studies
issue #26
Wearables can detect early dementia signs with 70-95% accuracy across 200,000+ people
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief