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Behavioral and molecular effects of prenatal continuous light exposure in the adult rat
Long-term behavior and brain changes in adult rats exposed to constant light before birth
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Abstract
Pregnant Wistar rats exposed to constant light during late gestation led to significant behavioral changes in their adult offspring.
- Adult offspring exhibited anxiety-like behavior and impaired short-term memory.
- Decreased levels of melatonin and serotonin were observed in brain samples from PCLE offspring.
- Increased levels of reactive oxygen species were detected in PCLE offspring.
- The serotonin reuptaker gene Slc6a4 showed decreased expression in the prefrontal cortex.
- The circadian rhythm-related gene Rora was upregulated in the amygdala of PCLE offspring.
- Results indicate dysregulation in serotonin and melatonin signaling and increased oxidative stress in PCLE offspring.
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