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Analysis of SNPs of MC4R , GNB3 and FTO gene polymorphism in obese Saudi subjects
Genetic variations linked to obesity in Saudi individuals
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Abstract
The FTO genotype TT is associated with increased weight, BMI, and leptin levels in Saudi subjects.
- Individuals with the FTO TT genotype showed higher body weight and BMI compared to those with other genotypes.
- Increased leptin levels were observed in both males and females carrying the FTO TT genotype.
- The GNB3 TT genotype was linked to a higher likelihood of obesity and also associated with elevated leptin levels.
- No significant association was found between the MC4R A822G SNP and obesity among the studied subjects.
- The presence of the homozygous AA genotype for MC4R was noted, but its impact on obesity could not be detected.
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