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Abstract
m6A RNA methylation is the most prevalent epitranscriptomic modification affecting various RNA types.
- m6A is a dynamic and reversible modification present in mRNA, rRNA, miRNA, lncRNA, circRNA, and snRNA.
- is an m6A demethylase associated with tumorigenesis and progression by influencing RNA metabolism and gene expression.
- Aberrant expression of ALKBH5 is frequently observed in multiple cancers, where it may promote tumor initiation and accelerate cancer cell proliferation.
- ALKBH5 could impact therapeutic responses in various malignancies, but its role in therapy responsiveness and drug resistance is not well understood.
- The review evaluates ALKBH5-mediated regulatory pathways in relation to chemotherapy, radiotherapy, and immunotherapy.
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