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Melatonin Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence
Melatonin shortage and its possible link to delirium: a summary of current research
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Abstract
Melatonin deficiency is associated with circadian rhythm disorders in patients with delirium and cognitive impairment.
- Delirium symptoms often overlap with those of dementia, including issues like sundowning.
- Circadian rhythm disturbances are common in individuals experiencing delirium.
- Melatonin plays a significant role in regulating the sleep-wake cycle in mammals.
- Therapeutic benefits of melatonin treatment have been observed in disorders related to delirium and dementia.
- Placebo-controlled randomized clinical trials have explored melatonin's effects in these patient populations.
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