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Abstract
Prolonged propofol anesthesia significantly impacts circadian rhythm, reducing oscillation amplitude of sleep and related physiological processes within 24 hours.
- Circadian rhythm disturbances may occur after general anesthesia, affecting sleep, body temperature, and movement.
- Prolonged propofol anesthesia inhibits the expression of circadian factors PER and CRY in the hypothalamus.
- Activation of the CAMK-CREB signaling pathway may be involved in the inhibition of these circadian factors.
- Post-translational factors such as GSK-3β, SIRT1, and AMPK may also play a role in regulating circadian factors following propofol anesthesia.
- Exogenous melatonin pretreatment could restore circadian rhythm by modulating circadian factor expression and reducing excessive melatonin synthesis.
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