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Melatonin and sleep in aging population
Melatonin levels and sleep patterns in older adults
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Abstract
A decreased production of melatonin with age is documented in a majority of studies.
- Melatonin is released from the pineal gland in response to the light-dark cycle.
- The rise in melatonin secretion at night is linked to the onset of sleep.
- Aging is associated with significant reductions in sleep continuity and quality.
- Alzheimer's disease is correlated with diminished nocturnal melatonin secretion and sleep/wake rhythm disturbances.
- Clinical trials suggest exogenous melatonin may improve sleep in elderly insomniacs and Alzheimer's patients.
- Ramelteon, a melatonin receptor analog, has been introduced as a new type of sleep aid without evidence of abuse or dependence.
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