Interactions among microbes, the immune system, and the circadian clock

Oct 9, 2020Seminars in immunopathology

How microbes, the immune system, and the body’s internal clock interact

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Abstract

The circadian clock influences host immune responses and microbial interactions throughout the day-night cycle.

  • Circadian rhythms synchronize immune cell functions with environmental light cycles.
  • Host immunity varies in effectiveness against pathogens depending on the time of day.
  • The circadian clock impacts the development and movement of immune cells.
  • There is a two-way communication between the circadian clock and the microbiota.
  • Microbial populations affect the regulation of host immunity and metabolic processes linked to the circadian clock.

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