Full text is available at the source.
The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock
Gut bacteria help match daily cycles of natural immunity with the body’s internal clock
AI simplified
Abstract
The intestinal microbiota generates diurnal rhythms in innate immunity that synchronize with feeding patterns.
- Circadian feeding behaviors in animals influence exposure to foodborne bacteria.
- Daily rhythms in epithelial attachment by segmented filamentous bacteria (SFB) drive rhythmic expression of antimicrobial proteins.
- The circadian clock regulates rhythmic SFB attachment through control of feeding rhythms.
- Activation of an immunological circuit involving group 3 innate lymphoid cells occurs with rhythmic SFB attachment.
- Epithelial STAT3 expression and activation exhibit oscillations, leading to variations in antimicrobial protein expression.
- Resistance to Salmonella Typhimurium infection varies across the day-night cycle, linked to host feeding rhythms.
AI simplified