Cell

Gut bacteria help match daily cycles of natural immunity with the body’s internal clock

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The intestinal microbiota generates diurnal rhythms in innate immunity that synchronize with feeding patterns.

  • Circadian feeding behaviors in animals influence exposure to foodborne bacteria.
  • Daily rhythms in epithelial attachment by segmented filamentous bacteria (SFB) drive rhythmic expression of antimicrobial proteins.
  • The circadian clock regulates rhythmic SFB attachment through control of feeding rhythms.
  • Activation of an immunological circuit involving group 3 innate lymphoid cells occurs with rhythmic SFB attachment.
  • Epithelial STAT3 expression and activation exhibit oscillations, leading to variations in antimicrobial protein expression.
  • Resistance to Salmonella Typhimurium infection varies across the day-night cycle, linked to host feeding rhythms.

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Competing interests

Declaration of interests The authors declare no competing interests.
PubMed

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