Full text is available at the source.
The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3
Gut bacteria influence daily cycles in body metabolism through a key enzyme
AI simplified
Abstract
The intestinal microbiota programs diurnal metabolic rhythms in the mouse small intestine through histone deacetylase 3 (HDAC3).
- The microbiota induced expression of intestinal epithelial HDAC3, which was rhythmically recruited to chromatin.
- This recruitment resulted in synchronized diurnal oscillations in histone acetylation, metabolic gene expression, and nutrient uptake.
- HDAC3 coactivated estrogen-related receptor α in a noncanonical manner, leading to microbiota-dependent rhythmic transcription of the lipid transporter gene.
- Enhanced lipid absorption was observed, which is associated with diet-induced obesity.
AI simplified