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High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction
High-fat diet disrupts gut immune protein and microbial daily rhythms linked to metabolism problems
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Abstract
High-fat diet impairs host metabolic homeostasis, resulting in arrhythmic host Reg3γ expression.
- Gut microbial rhythms are influenced by diet and host factors.
- The host antimicrobial peptide Reg3γ interacts with key ileal microbes.
- There is no correlation between Reg3γ expression and the intestinal core circadian clock.
- Dietary influences disrupt the oscillation of gut microbes and host metabolism.
- Restoring gut microbial sensing of dietary signals may help improve metabolic dysfunction.
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