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Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Cross-species control of daily gut bacteria cycles supports metabolic balance
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Abstract
The intestinal microbiota in both mice and humans shows diurnal oscillations influenced by feeding rhythms.
- Diurnal changes in microbiota composition and function occur throughout the day.
- Disruption of host molecular clock components or jet lag leads to abnormal microbiota fluctuations.
- Aberrant feeding rhythms are associated with dysbiosis in the microbiota.
- Dysbiosis induced by jet lag contributes to glucose intolerance and obesity.
- These metabolic disturbances can be transferred to germ-free mice through fecal transplantation.
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