Nature reviews. Microbiology

How microbes influence heart and blood vessel disease

Updated

Abstract

Recent findings indicate that gut microbial metabolism may significantly influence cardiovascular disease (CVD) risk.

  • Diet contributes to the development of cardiovascular disease through complex interactions with gut microbes.
  • Microbial-associated molecular patterns are recognized by host receptors and may play a role in CVD pathogenesis.
  • The gut microbiota generates metabolites like trimethylamine-N-oxide and short-chain fatty acids that can impact cardiovascular health.
  • Targeting host-microbe interactions could be a promising strategy for preventing or treating cardiovascular disease.
  • Further research is necessary to establish direct causal links between microbial mechanisms and the development of CVD.

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Full Text

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Funding

Competing interests

Competing interests statement . S.L.H. is named as inventor on pending and issued patents held by the Cleveland Clinic relating to cardiovascular diagnostics and therapeutics. He is also a paid consultant for Esperion and P&G, and has received research funds from Astra Zeneca, P&G, Pfizer Inc., Roche Diagnostics, and Takeda. S.L.H. has also received royalty payments for inventions or discoveries related to cardiovascular diagnostics or therapeutics from Cleveland HeartLab, Esperion and Siemens. J. M. B declares no competing interests.
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