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Mirtazapine: pharmacology in relation to adverse effects
How Mirtazapine’s actions relate to its side effects
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Abstract
Mirtazapine is associated with a different side effect profile compared to traditional antidepressants.
- Mirtazapine is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).
- It produces less alpha 1 adrenergic and muscarinic blockade than tricyclic antidepressants.
- The drug may cause significantly less nausea and sexual dysfunction than selective serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline reuptake inhibitors (SNRIs).
- Its unique pharmacology stems from its blockade of 5-HT2 and 5-HT3 receptors.
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