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Modulation of Clock Gene Expression by the Transcriptional Coregulator Receptor Interacting Protein 140 (RIP140)
How the protein RIP140 affects the activity of genes that control the body’s internal clock
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Abstract
RIP140 mRNA and protein levels are regulated by circadian rhythms.
- RIP140 may modulate the expression of clock genes, indicating its potential role in the circadian clock.
- The absence of RIP140 is associated with disrupted basal levels of BMAL1 and other clock genes.
- Loss of RIP140 reduces the amplitude of oscillations in clock gene expression.
- RIP140 is recruited to specific sites on the BMAL1 promoter and interacts with RORα.
- This interaction suggests that RIP140 increases transcription of BMAL1 in a manner dependent on RORα.
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