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Diversification of the molecular clockwork for tissue-specific function: insight from a novel Drosophila Clock mutant homologous to a mouse Clock allele
Changes in the Molecular Clock for Different Tissue Functions Seen in a New Fruit Fly Clock Mutation Similar to a Mouse Clock Gene
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Abstract
Amino acids 657-707 of dCLOCK are critical for its interaction with PERIOD and transcriptional activation in Drosophila.
- The circadian clock system helps organisms adapt to daily environmental changes.
- In Drosophila, the interaction between dCLOCK and PERIOD is essential for regulating circadian gene expression.
- Flies lacking amino acids 657-707 in dCLOCK show disruptions in molecular rhythms in specific pacemaker neurons.
- Light-sensitive pacemaker neurons exhibit significant disruptions, while temperature-sensitive neurons remain unaffected.
- The findings indicate that dCLOCK's role in the circadian clock may vary depending on the type of pacemaker neuron.
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