Biochemical and biophysical research communications

Identifying the genetic code for the red pigment concentrating hormone in crustaceans

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

A cDNA encoding the precursor of the red pigment concentrating hormone (RPCH) was isolated from the shore crab, Carcinus maenas.

  • The preprohormone sequence includes a 25 amino acid signal peptide and an eight amino acid RPCH sequence.
  • A Gly acts as an amide donor in the precursor structure.
  • The sequence also contains a dibasic processing site and a 74 residue peptide of unknown function, termed RPCH-precursor-related peptide (RPRP).
  • In situ hybridization showed the RPCH gene transcript localized in two clusters of neurons in the medulla terminalis of the eyestalk.

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