Manufacturing mRNA-Loaded Lipid Nanoparticles with Precise Size and Morphology Control

Lipid nanoparticles produced by the new method show up to an 8-fold increase in transfection efficacy compared to conventional methods.

• The new method allows for independent control over the size and shape of lipid nanoparticles.
• Decoupling particle design from mixing enhances the ability to engineer lipid nanoparticles with specific properties.
• Mixing under high fusogenicity conditions is utilized to optimize the lipid nanoparticle assembly process.
• Timely post-injection of an aqueous buffer helps achieve desired lipid nanoparticle characteristics.
• The approach improves quality control and aids in predictive modeling for lipid nanoparticle production.

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