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High-Throughput Formulation Using Fast mRNA Lipid Nanoparticle Assembly via Simple Thermomixing (HTF-FLASH)
Fast mRNA Lipid Nanoparticle Preparation Using Simple Heat Mixing for High-Throughput Formulation
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Abstract
The HTF-FLASH technique enables rapid production of lipid nanoparticles within a minute.
- HTF-FLASH uses a thermomixer and a 96-deep-well plate for efficient formulation.
- Lipid nanoparticles produced with HTF-FLASH show comparable physicochemical properties to those made via microfluidic methods.
- The approach may help reduce batch-to-batch variability associated with traditional formulation techniques.
- This method could enhance the efficiency of mRNA transfection in screening workflows.
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