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Abstract
Messenger RNA (mRNA) has rapidly emerged as a transformative therapeutic modality with applications in infectious diseases, oncology, and genetic disorders.
- Chemical programmability of mRNA enables the introduction of synthetic modifications across various regions of the molecule.
- Recent advances in topological engineering are influencing RNA stability, immune response, and translation efficiency.
- Innovative synthesis strategies are being developed for linear, circular, and branched mRNA structures.
- Understanding structure-activity relationships is crucial for optimizing translation efficiency, decay rates, and immune activation.
- There is a growing interest in the implications of engineered mRNA for next-generation therapeutics.
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