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Abstract
Recent advances in single-cell and spatial transcriptomic technologies have identified novel rejuvenation targets for skin aging.
- Skin aging involves a decline in tissue structure, function, and regenerative capacity.
- Current interventions primarily alleviate symptoms rather than address the underlying molecular mechanisms of aging.
- High-resolution atlases have revealed cell type-specific transcriptional programs and new regulators of skin health.
- Candidate rejuvenation targets include intracellular regulatory proteins that are challenging to manipulate with traditional drugs.
- RNA engineering has advanced nucleic acid therapeutics, particularly messenger RNA, for restoring proteins lost during aging.
- Innovations in delivery methods, such as lipid nanoparticles and microneedles, enhance the potential for effective skin treatment.
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