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Abstract
mRNA vaccines may enhance cancer treatment by encoding antigens and modulating immune responses.
- Synthetic mRNA engineering involves optimizing structural elements, modifying nucleosides, and adjusting codon usage to enhance stability and translation efficiency.
- Diverse antigen strategies include tumor-associated antigens, neoantigens, and cryptic antigens derived from aberrant splicing variants.
- Lipid nanoparticles and dendritic cell-based systems are explored as delivery platforms to improve mRNA biodistribution and immune activation.
- mRNA vaccines can stimulate antitumor responses by encoding specific antigens and supporting adoptive T cell therapies.
- Combining mRNA vaccines with immune checkpoint inhibitors shows promise for treating various solid tumors and hematologic malignancies.
- Innovations such as targeted lipid nanoparticle platforms and AI-assisted vaccine design may further advance mRNA technology in cancer immunotherapy.
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