Molecular differences behind varied aging in multiple body systems

This study maps multi-omic signals that may explain why aging differs across organ systems.

The evidence is an integrative multi-omic analysis combining genomic, epigenomic, transcriptomic, proteomic, and metabolomic data for nine organ-specific aging clocks and four blood-based epigenetic clocks.

The abstract reports correlations, prioritized targets, biomarkers, and a molecular network, but does not show that these targets delay organ-specific aging or prevent chronic disease.