Multicomponent Synergistic Antibacterial Hydrogel Based on Gelatin-Oxidized Carboxymethyl Cellulose for Wound Healing of Drug-Resistant Chronic Infection

Apr 23, 2024ACS applied bio materials

Gelatin and Modified Cellulose Hydrogel Working Together to Heal Drug-Resistant Chronic Wound Infections

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Regenerative Health on OpenScience ↗PubMed ↗DOI ↗

Abstract

The hydrogel developed achieves an antibacterial rate close to 100% against drug-resistant bacteria.

Quaternized poly(vinyl alcohol) and copper-doped polydopamine nanoparticles are combined into a hydrogel for enhanced antibacterial properties.
Polydopamine improves the compatibility of the hydrogel and prevents the loss of copper nanoparticles.
The hydrogel exhibits rapid bactericidal effects when exposed to near-infrared light.
In a wound healing model, the hydrogel controls inflammation and promotes tissue repair processes like collagen deposition and angiogenesis.
This approach offers a potential solution for treating chronic wounds infected by antibiotic-resistant bacteria.

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Bacterial invasion hinders the healing process of wound, leading to the formation of chronic infected wound; meanwhile, the misuse of antibiotics has resulted in the emergence of numerous drug-resistant bacteria. The application of conventional antimicrobial methods and wound treatment techniques is not appropriate for wound dressings. In this paper, quaternized poly(vinyl alcohol) (QPVA) and pomegranate-like copper uniformly doped polydopamine nanoparticles (PDA@Cu) were introduced into a gelatin-oxidized carboxymethyl cellulose system to form a multicomponent synergistic antibacterial hydrogel (GOQP). Polydopamine improves the biocompatibility and prevents the detachment of Cu nanoparticles. It can achieve synergistic antibacterial effects through quaternary ammonium salt-inorganic nanoparticle photothermal treatment under 808 nm near-infrared (NIR) irradiation. It exhibits highly efficient and rapid bactericidal properties against,, and(methicillin-resistant) with an antibacterial rate close to 100%. The gel scaffold composed of macromolecules gives the hydrogel excellent mechanical properties, adhesive capabilities, self-healing characteristics, biocompatibility, and pH degradation and promotes cell adhesion and migration. In a full-thickness wound healing model infected with, GOQPcontrols inflammatory responses, accelerates collagen deposition, promotes angiogenesis, and enhances wound closure in the wound healing cascade reaction. This study provides a feasible strategy for constructing dressings targeting chronic infection wounds caused by drug-resistant bacteria. 3 3 3 3Escherichia coli Staphylococcus aureus MRSA Staphylococcus aureus MRSA

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Multicomponent Synergistic Antibacterial Hydrogel Based on Gelatin-Oxidized Carboxymethyl Cellulose for Wound Healing of Drug-Resistant Chronic Infection

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