Polydopamine-armored zeolitic imidazolate framework-8-incorporated zwitterionic hydrogel with multifunctional properties for infected wound healing

Jun 30, 2024International journal of biological macromolecules

Multi-purpose antibacterial hydrogel with protective coating for healing infected wounds

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Regenerative Health on OpenScience ↗PubMed ↗DOI ↗

Abstract

The hydrogel dressing achieved 99.6% antibacterial efficacy against E. coli.

The hydrogel combines polydopamine-armored nanoparticles with a zwitterionic polymer for enhanced properties.
It demonstrates good adhesion (14.7 kPa) and tensile strength (83.2 kPa) suitable for skin applications.
In vitro results show the hydrogel promotes fibroblast proliferation, migration, and endothelial cell growth.
In vivo testing indicates the hydrogel effectively suppresses bacterial growth in infected wounds.
The sustained Zn-release function is maintained, aiding in the healing of both normal and diabetic wounds.

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Diabetic skin wound healing is compromised by bacterial infections, oxidative stress, and vascular disruption, leading to delayed recovery and potential complications. This study developed an antibacterial, antioxidant, and adhesive hydrogel dressing that promotes rapid bacterial-infected diabetic wound healing using the biological macromolecule of polydopamine (PDA). This hydrogel comprised PDA-armored zeolitic imidazolate framework-8 nanoparticles (PDA@ZIF-8 NPs) combined with a second armor of zwitterionic polymer network (poly(acrylamide-co-sulfobetaine methacrylate); PAS), realizing low concentration Znrelease, good adhesion (14.7 kPa for porcine skin), and improved tensile strength (83.2 kPa). The hydrogel exhibited good antibacterial efficacy against both Staphylococcus aureus (S. aureus, 92.8 %), Escherichia coli (E. coli, 99.6 %) and methicillin-resistant S. aureus (MRSA, 99.2 %), which was attributed to the properties of the incorporated PDA@ZIF-8 NPs. Notably, in vitro, the PDA@ZIF-8 PAS hydrogel not only promoted fibroblast proliferation and migration but also facilitated endothelial cell angiogenesis. In vivo, the PDA@ZIF-8 PAS hydrogel retained its Zn-releasing function and effectively suppressed bacterial growth in infected wounds, thereby accelerating the regeneration of both normal and diabetic wounds. This multiarmored hydrogel is a promising sustained-release carrier for functional metal ions and drugs, making it applicable for not only skin healing, but potentially the regeneration of other complex tissues. 2+ 2+

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Polydopamine-armored zeolitic imidazolate framework-8-incorporated zwitterionic hydrogel with multifunctional properties for infected wound healing

Abstract

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