Loss of myometrial oxytocin receptors during oxytocin-induced and oxytocin-augmented labour

Sep 28, 2000Journal of reproduction and fertility

Decrease of oxytocin receptors in uterine muscle during labor started or strengthened by oxytocin

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Abstract

The concentration of myometrial oxytocin receptors decreased from 477 fmol mg(-1) protein before labour to 118 fmol mg(-1) protein during oxytocin-induced labour.

  • Oxytocin receptors in the myometrium may undergo desensitization during labour.
  • Receptor concentration dropped significantly during prolonged oxytocin-augmented and oxytocin-induced labour.
  • Oxytocin receptor mRNA levels decreased by 60-fold during oxytocin-augmented labour and 300-fold during oxytocin-induced labour.
  • Findings suggest that oxytocin infusion could lead to reduced receptor availability in vivo.

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