Myometrial steroid concentration and oxytocin receptor density in parturient women at term

Oxytocin receptor density was significantly lower in oxytocin-resistant labor compared to successful oxytocin-augmented labor.

• A total of 50 term pregnant women were categorized based on their labor status: not in labor, normal labor, successful oxytocin-augmented labor, and oxytocin-resistant labor.
• Oxytocin receptor concentration was significantly lower in non-labor patients compared to those in spontaneous normal labor and successful oxytocin-augmented labor.
• There is a positive relationship between the progress of cervical dilatation (cm/h) and oxytocin receptor density in the myometrium.
• The concentrations of progesterone and estradiol did not differ among the different labor types or states of uterine contractile activity.
• Individual myometrial sensitivity may be an important factor influencing the response to administered oxytocin in humans.

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