Effects of estradiol and interaction with progesterone or oxytocin on term human myometrial contractile activity

Estradiol at 0.1 and 1 microgram/mL increased contractile frequency and decreased myometrial tonus in human tissue samples.

• Estradiol significantly increased the frequency of contractions while decreasing the tonus and activity area of contractions compared to control.
• No significant differences were observed in contraction frequency between strips treated with estradiol plus progesterone and those treated with progesterone alone.
• Myometrial tonus was reduced by estradiol in combination with progesterone compared to progesterone alone.
• There were no significant differences in contraction frequency between strips treated with estradiol plus oxytocin and those treated with oxytocin alone.
• Estradiol combined with oxytocin decreased myometrial tonus and reduced the activity area of contractions compared to oxytocin alone.

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