N,N-dimethyltryptamine produces antidepressant and anxiety-reducing effects in helpless mice compared to S-ketamine

DMT (10 mg/kg) produced antidepressant effects in helpless mice, comparable to those of S-ketamine (10 mg/kg).

• Both DMT and S-ketamine reversed escape deficits in group-housed mice 24 hours after administration.
• DMT and S-ketamine prevented stress-induced anhedonia in single-housed mice 5 days post-treatment.
• DMT reduced immobility in the tail suspension test for up to 8 days, while S-ketamine effects lasted up to 30 hours.
• DMT reversed stress-induced reduced movement in the open field test and increased exploration in the elevated plus-maze for up to 5 days.
• Neither DMT nor S-ketamine affected behavior in the novelty-suppressed feeding test at 8 days post-administration.

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