Natural compounds that influence immune cell timing in asthma: current knowledge and challenges

Pulmonary circadian dysfunction is linked to nocturnal asthma and airway remodeling.

• Dysregulation of core clock genes in macrophages is associated with metabolic changes and signaling that promotes fibrosis.
• Natural bioactive compounds may provide a potential therapeutic approach by modulating the circadian clock.
• The connection between circadian rhythms and asthma suggests that timing may play a role in asthma management.

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