How Metabolism Controls the Brain's Immune Response in Health and Disease

Neuroimmunometabolism explores how microglia adjust their metabolism to influence immune functions in the central nervous system.

• Microglia alter their metabolic pathways to modify immune responses in the brain.
• Neurons may communicate with microglia and influence their immune functions through metabolic signals.
• The metabolic environment of the brain and microglial metabolism play critical roles in neuroimmune responses in both healthy and diseased states.
• Dysregulation of metabolic substrates could impact neuroimmune responses and contribute to psychiatric disorders.
• Metabolic reprogramming of microglia is proposed as a potential strategy for managing neuroinflammation-related brain disorders.

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